How about an RPG about the typical eternally-recurring apocalypse that Our Heroes must rise up against and find an impossible solution to against great odds, in a setting full of destroyed ancient civilizations and a populace who doesn't believe it can happen again
but it's about the microbes in your mouth, and the apocalypse is your nightly use of mouthwash.
Once again, shoutout to the bots that re-toot anything with the #Gaming hashtag <3